The Laboratoire de Biophysique Moléculaire aux Interfaces (LBMI) is part of the “Chimie des agrobiosystèmes” axis in the AGROBIOCHEM Department of Gembloux Agro-Bio Tech and of the biophysics platform. The unit is a research laboratory devoted to molecular biophysics and computer assisted modelling. Our research activities are mainly focused on the study of the interaction between biomolecules (from proteins to small organic molecules) with the membrane by complementary biophysical tools to understand their structure/activity relationships.



Magali Deleu and Laurence Lins are Guest Editors of a Special Issue on « SAR out of the Box » in IJMS


IJMS special issue


!New publications from LBMI!

Claereboudt, E, Eeckhaut, I, Lins, L*, Deleu, M* (2018) How different sterols contribute to saponin tolerant plasma membranes in sea cucumbers. Sci Rep, 8, 10845

Claereboudt, E, Sci Rep

Lebecque, S, Crowet, JM, Lins,L, delory, B, Du Jardin, P, Fauconnier, ML, Deleu, M. (2018) Interaction between the barley allelochemical compounds gramine and hordenine and artificial lipid bilayers mimicking the plant plasma membrane. Sci. Rep., 8, 9784

Lebecque, Sci Rep

Crowet, JM, Nasir, MN, Dony, N, Deschamps, A, Stroobant, V, Morsomme, P, Deleu, M, Soumillion P, Lins, L (2018) Insight into the self asembling properties of peptergents : a molecular dynamics simulation study. IJMS, 19, 2772

Crowet, IJMS


Jules Petit, one of our PhD students was rewarded twice for his communication at the SFR Condorcet young student day and at the GEM congress:


New article published in Science in collaboration with Pr T. Nürnberger lab and Pr S. Mongrand Lab

« Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins » T. Lenarcic et al, 2017, 358, 1431-1434


figGIPC series A B_300dpi


Our eLife article in the spotlight on the ULiege website



LBMI’s lab was co-organisor of the XIX GEM (Groupe d’Etude des Membranes) that was held at Roscoff in november 2017.



Presentation of Valbran on Daily Science




Our new article published in eLife !!

Structural Basis for Plant Plasma Membrane Protein Dynamics and Organization into Functional Nanodomains (DOI: 10.7554/eLife.26404, ULg press release)

Julien Gronnier1, Jean-Marc Crowet2#, Birgit Habenstein5#, Mehmet Nail Nasir2#, Vincent Bayle4#, Eric Hosy6, Matthieu Pierre Platre4, Paul Gouguet1, Sylvain Raffaele3, Denis Martinez5, Axelle Grelard5, Antoine Loquet5, Françoise Simon-Plas7, Patricia Gerbeau-Pissot7, Christophe Der7, Emmanuelle M. Bayer1, Yvon Jaillais4, Magali Deleu2, Véronique Germain1, Laurence Lins2*, Sébastien Mongrand1*

1, Laboratoire de Biogenèse Membranaire (LBM), Unité Mixte de Recherche UMR 5200, CNRS, Université de Bordeaux, 71 avenue Edouard Bourlaux, 33883 Villenave d’Ornon Cedex France
2, Laboratoire de Biophysique Moléculaire aux Interfaces, GX ABT, Université de Liège, B-5030 Gembloux, Belgium
3, LIPM, Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France
4, Laboratoire Reproduction et Développement des Plantes, Université de Lyon, ENS de Lyon, Université Claude Bernard Lyon 1, CNRS, INRA, F-69342 Lyon, France
5, Institute of Chemistry & Biology of Membranes & Nanoobjects (UMR5248 CBMN), CNRS, Université de Bordeaux, Institut Polytechnique Bordeaux, All. Geoffroy Saint-Hilaire, 33600 Pessac, France
6, Interdisciplinary Institute for Neuroscience, CNRS, University of Bordeaux, UMR 5297
7, Agroécologie, AgroSup Dijon, INRA, Univ. Bourgogne Franche-Comté, F-21000 Dijon, France, ERL 6003 CNRS, , BP 86510, F–21000 Dijon, France

The membrane is a barrier that allows exchange with the environment and also prevents pathogens to penetrate cells. Lipids and membrane proteins are notably able to induce signals that enhance cellular responses after a pathogen attack. Plants have also very efficient immune system and it was recently shown that one plant membrane protein called REMORIN (REM) is implied in the fight against viruses by preventing their propagation. To understand how this protein is anchored to the membrane and how its membrane localisation is involved in the antiviral response, a collaboration between five french teams and our lab has demonstrated the importance of the segregation of REM into functional lipid domains. By our multidisplinary approach bridging biophysics, biochemistry, structural and plant biology, we have shown that REM is bound to specific lipids from the inner leaflet of the plasma membrane (called phosphoinositides) by an unconventional anchor that induces the formation of REM-enriched lipid domains. The dynamic and aggregating properties of those domains are crucial for inducing antiviral responses. This study opens the way for understanding at a molecular level how plants respond to pathogen attacks and what is the role of the plasma membrane in those molecular processes.



 FIELD project rewarded again by an international prize in Florence, Italy during EuroFedLipids Conference

Dr Mehmet Nail NASIR won three international scientific prizes in one year .
For that event, the website of Gembloux Agro-Bio Tech- University of Liege has published this article.

Dr. Mehmet Nail NASIR during the ceremony of EuroFedLipids in Florence, Italy

Monday 11 may 2015: when Field meets Eliderham and Maelia




Relevant publications

Complementary biophysical tools to investigate lipid specificity in the interaction between bioactive molecules and the plasma membrane: A review.

Magali Deleu, Jean-Marc Crowet, Mehmet N. Nasir, Laurence Lins *

Biochim Biophys Acta. 2014 Dec;1838(12):3171-3190

doi: 10.1016/j.bbamem.2014.08.023