The Laboratoire de Biophysique Moléculaire aux Interfaces (LBMI) is part of the “Chimie des agrobiosystèmes” axis in the AGROBIOCHEM Department of Gembloux Agro-Bio Tech and of the biophysics platform. The unit is a research laboratory devoted to molecular biophysics and computer assisted modelling. Our research activities are mainly focused on the study of the interaction between biomolecules (from proteins to small organic molecules) with the membrane by complementary biophysical tools to understand their structure/activity relationships.

 


 

News & Events

Presentation of Valbran on Daily Science

« VALBRAN VA METTRE DU SON DE BLÉ DANS VOTRE LESSIVEUSE »

on http://dailyscience.be/2017/09/27/valbran-va-mettre-du-son-de-ble-dans-votre-lessiveuse/

 

Our new article published in eLife !!

Structural Basis for Plant Plasma Membrane Protein Dynamics and Organization into Functional Nanodomains (DOI: 10.7554/eLife.26404, ULg press release)

Julien Gronnier1, Jean-Marc Crowet2#, Birgit Habenstein5#, Mehmet Nail Nasir2#, Vincent Bayle4#, Eric Hosy6, Matthieu Pierre Platre4, Paul Gouguet1, Sylvain Raffaele3, Denis Martinez5, Axelle Grelard5, Antoine Loquet5, Françoise Simon-Plas7, Patricia Gerbeau-Pissot7, Christophe Der7, Emmanuelle M. Bayer1, Yvon Jaillais4, Magali Deleu2, Véronique Germain1, Laurence Lins2*, Sébastien Mongrand1*

1, Laboratoire de Biogenèse Membranaire (LBM), Unité Mixte de Recherche UMR 5200, CNRS, Université de Bordeaux, 71 avenue Edouard Bourlaux, 33883 Villenave d’Ornon Cedex France
2, Laboratoire de Biophysique Moléculaire aux Interfaces, GX ABT, Université de Liège, B-5030 Gembloux, Belgium
3, LIPM, Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France
4, Laboratoire Reproduction et Développement des Plantes, Université de Lyon, ENS de Lyon, Université Claude Bernard Lyon 1, CNRS, INRA, F-69342 Lyon, France
5, Institute of Chemistry & Biology of Membranes & Nanoobjects (UMR5248 CBMN), CNRS, Université de Bordeaux, Institut Polytechnique Bordeaux, All. Geoffroy Saint-Hilaire, 33600 Pessac, France
6, Interdisciplinary Institute for Neuroscience, CNRS, University of Bordeaux, UMR 5297
7, Agroécologie, AgroSup Dijon, INRA, Univ. Bourgogne Franche-Comté, F-21000 Dijon, France, ERL 6003 CNRS, , BP 86510, F–21000 Dijon, France

The membrane is a barrier that allows exchange with the environment and also prevents pathogens to penetrate cells. Lipids and membrane proteins are notably able to induce signals that enhance cellular responses after a pathogen attack. Plants have also very efficient immune system and it was recently shown that one plant membrane protein called REMORIN (REM) is implied in the fight against viruses by preventing their propagation. To understand how this protein is anchored to the membrane and how its membrane localisation is involved in the antiviral response, a collaboration between five french teams and our lab has demonstrated the importance of the segregation of REM into functional lipid domains. By our multidisplinary approach bridging biophysics, biochemistry, structural and plant biology, we have shown that REM is bound to specific lipids from the inner leaflet of the plasma membrane (called phosphoinositides) by an unconventional anchor that induces the formation of REM-enriched lipid domains. The dynamic and aggregating properties of those domains are crucial for inducing antiviral responses. This study opens the way for understanding at a molecular level how plants respond to pathogen attacks and what is the role of the plasma membrane in those molecular processes.

eLife

 

Conference given during EuroFed Lipids Congress in Ghent

Eurofed Lipids Congress is taken place in Ghent at the International Conference Center (ICC) with the participation of scientists around the Europe and the World. The congress covered different topics from Health and Nutrition to Physical-chemistry.

During the congress, our lab member, Dr. Mehmet Nail NASIR, gave a conference on our recent studies on sugar-based bolaamphiphiles and their potential use as drug delivery agents. This work has been co-signed by Dr. Laurence LINS, Dr. Magali DELEU, Dr. Jean-Marc CROWET from LBMI lab and by the researchers from Institut de Chimie Moléculaire de Reims.

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Mehmet Nail NASIR giving a talk

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Mehmet Nail NASIR giving a talk

 

Participation of LBMI lab to the Joint Meeting of the Membrane Sections of the French and German Biophysical Societies 

Dr. Laurence LINS, Dr. Magali DELEU, Dr. Jean-Marc CROWET and Dr. Mehmet Nail NASIR from the LBMI lab participated to the this meeting, helded in Bad Herrenalb in Germany. The conference site « Haus der Kirche – Evangelische Akademie Baden » was located close to the historical center of Bad Herrenalb, a spa in the northern outskirts of the Black Forest. This conference was organized jointly by French and German Biophysical Societies with the participation of more than 100 scientists from Europe and overseas in an inspiring environment of scientific exchange and discussion. In this environment, the LBMI lab members gave a talk and presented two posters.

 

 

Dr. Laurence LINS giving a talk

Dr. Laurence LINS giving a talk

Dr. Magali DELEU giving a talk

Dr. Magali DELEU giving a talk

Dr. Mehmet Nail NASIR during poster presentation

Dr. Mehmet Nail NASIR during poster presentation

Dr. Jean-Marc CROWET during a poster presentation

Dr. Jean-Marc CROWET during a poster presentation

LBMI lab members- Laurence LINS, Magali DELEU, Mehmet Nail NASIR, Jean-Marc CROWET

LBMI lab members- Laurence LINS, Magali DELEU, Mehmet Nail NASIR, Jean-Marc CROWET

 

 

 


Participation of LBMI lab to the GERLI meeting helded in Bischofsheim, France

 

Dr. Laurence LINS, Dr. Magali DELEU, Dr. Jean-Marc CROWET and Dr. Mehmet Nail NASIR from the LBMI lab participated to the GERLI meeting.
This meeting takes place every two years with the participation of international scientists working on lipids. This time, the meeting helded at the conference center « Le Bischenberg » in Bischoffsheim, in the Strasbourg and Obernai area. The LBMI lab members presented a poster  and gave a conference.

Dr. Mehmet Nail NASIR during the conference.

Dr. Mehmet Nail NASIR during the conference.

Dr. Magali DELEU during the flash presentation of the poster.

Dr. Magali DELEU during the flash presentation of the poster.

 

 

 

 

 

 

 

 

 

 

 

 

 

FIELD project rewarded again by an international prize in Florence, Italy during EuroFedLipids Conference

Dr Mehmet Nail NASIR won three international scientific prizes in one year .
For that event, the website of Gembloux Agro-Bio Tech- University of Liege has published this article.

Dr. Mehmet Nail NASIR during the ceremony of EuroFedLipids in Florence, Italy

Monday 11 may 2015: when Field meets Eliderham and Maelia

photo_field_mai2015

 


 

Relevant publications

Complementary biophysical tools to investigate lipid specificity in the interaction between bioactive molecules and the plasma membrane: A review.

Magali Deleu, Jean-Marc Crowet, Mehmet N. Nasir, Laurence Lins *

Biochim Biophys Acta. 2014 Dec;1838(12):3171-3190

doi: 10.1016/j.bbamem.2014.08.023

Figure_2_abstractok