For more than 20 years at the former Centre de Biophysique Moléculaire Numérique (CBMN), we have been using our experience in molecular description of cell membrane components (lipids, proteins, peptides, pharmacological drugs) to attempt to predict the three-dimensional structure of macromolecules, notably with the successful development of Peplook for peptide structure prediction.
The group has recently been joined by the team of Dr Magali Deleu from Gembloux Agro-Bio Tech.
Research activities are currently focused on the study of the structure/membrane activity relationships of biobased molecules interacting with lipids via complementary biophysical tools. These approaches include notably Langmuir trough, infrared and fluorescence spectroscopies, circular dichroism, ITC and molecular modelling. Bioinformatics tools are homemade computer softwares and molecular dynamics approaches.